An autosomal locus controls sex reversal in interspecific XY hybrids of the medaka fishes
نویسندگان
چکیده
منابع مشابه
Wild-derived XY sex-reversal mutants in the Medaka, Oryzias latipes.
The medaka, Oryzias latipes, has an XX/XY sex-determination mechanism. A Y-linked DM domain gene, DMY, has been isolated by positional cloning as a sex-determining gene in this species. Previously, we found 23 XY sex-reversed females from 11 localities by examining the genotypic sex of wild-caught medaka. Genetic analyses revealed that all these females had Y-linked gene mutations. Here, we aim...
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Sex chromosomes and the sex-determining (SD) gene are variable in vertebrates. In particular, medaka fishes in the genus Oryzias show an extremely large diversity in sex chromosomes and the SD gene, providing a good model to study the evolutionary process by which they turnover. Here, we investigated the sex determination system and sex chromosomes in six celebensis group species. Our sex-linka...
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Patients with 46,XY gonadal dysgenesis (GD) exhibit genital anomalies, which range from hypospadias to complete male-to-female sex reversal. However, a molecular diagnosis is made in only 30% of cases. Heterozygous mutations in the human FGFR2 gene cause various craniosynostosis syndromes including Crouzon and Pfeiffer, but testicular defects were not reported. Here, we describe a patient whose...
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The regulation of gene expression is essential for organismal form, function, and fitness. Complex organismal development from zygote to adult requires finely tuned expression of genes in space, time, and abundance. Proper expression of genes is also required for most other aspects of physiology and function. Even minor changes in gene expression have the potential to significantly impact pheno...
متن کاملXY sex reversal and gonadal dysgenesis due to 9p24 monosomy.
We describe a case of XY sex reversal, gonadal dysgenesis, and gonadoblastoma in a patient with a deletion of 9p24 due to a familial translocation. The rearranged chromosome 9 was inherited from the father; the patient's karyotype was 46,XY,der(9)t(8;9) (p21;p24)pat. A review shows that 6 additional patients with 46,XY sex reversal associated with monosomy of the distal short arm of chromosome ...
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ژورنال
عنوان ژورنال: Heredity
سال: 2011
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.2011.38